Central Nervous System Disorders and Therapeutics

Neurochemical Transmission

Regardless of the type of neuron under consideration, the fundamental steps in chemical transmission are the same. Each of these steps is a potential site for pharmacological intervention in the normal transmission process:

1. Synthesis of the transmitter

2. Storage of the transmitter

3. Release of the transmitter by a nerve action potential

4. Interaction of the released transmitter with receptors on the effector cell membrane and the associated change in the effector cell

5. Rapid removal of the transmitter from the vicinity of the receptors

6. Recovery of the effector cell to the state that preceded transmitter action

• Dopamine
• Interneurons: Coordinators of Neuronal Synchrony
• Advances in Astrocyte-Neuron Interactions in Health and Disease
• Neurotransmission Receptors
• Chemical Neurotransmitters
• Human Synapses
• Monoamines
• Neuropeptides
• Serotonin
• Drug interaction in Various Stages in Neurotransmitters